To evaluate whether second-hand exposure to e-cigarette vapor results in exposure to any toxic chemicals, as well as evaluate physiologic responses to such exposure.
In a realistic setting (regular room and not closed chamber) we will invite vapers to vape for few hours ad-lib.
(non-vapers, non-smokers) will also be present in the room, with their heart rate and blood pressure monitored at regular intervals. Specialized equipment will be used to collect air samples and measure particulate matter, nicotine levels, aldehydes, volatile organic compounds and total organic carbon.
In a second session, smokers will be asked to smoke in the same room (which would have been meticulously cleaned after the e-cigarette session). Similarly to the previous session, non-smokers will be present to the room, with their blood pressure and heart rate monitored. Again, air samples will be collected, to measure toxic emissions. Blood samples can be obtained from the volunteers (non-smokers) to assess plasma nicotine levels before and after exposure to second-hand vaping and smoking. In a parallel experiment, we will visit and obtain air samples of houses of vapers and smokers (as well as non-smokers) at random times, to check the level of emissions inside the house.
A comparison between second hand smoking and vaping will be performed.
To evaluate whether flavored electronic cigarette liquid is more effective in acutely suppressing smoking craving in a group of smokers, compared to unflavored liquid.
A randomized double-blind controlled study evaluating flavored liquids compared to controlled unflavored liquid. Smokers will be asked to use liquids with 18mg/ml nicotine concentration in two sessions, in a randomized, blinded cross over design. On one session they will use an unflavored liquid. On a second session they will choose from a selection of four flavored liquids. Plasma nicotine levels will be assessed before and after each session, and questionnaires will be used to evaluate nicotine and smoking craving, satisfaction, acceptability and preference of use in future quit attempts.
Approximately 30 smokers will be needed for this study
The acceptability, experience and efficacy of flavored liquid compared to unflavored base will be evaluated. Depending on funding, a third session of using flavored zero–nicotine liquid will also be performed.